ToolUniverse Disease Research

The agent generates a comprehensive, citation-backed disease research report by creating a markdown file and progressively updating it across 10 research dimensions.

IMPORTANT: The agent should always use English disease names and search terms in tool calls, even if the user writes in another language. Original-language terms should only be tried as a fallback if English returns no results. The agent responds in the user's language.

When to Use

This skill applies when the user:

• Asks about any disease, syndrome, or medical condition
• Needs comprehensive disease intelligence
• Wants a detailed research report with citations
• Asks "what do we know about [disease]?"

Core Workflow: Report-First Approach

The agent should not show the search process to the user. Instead it follows this pattern:

1. Create report file — Initialize {disease_name}_research_report.md with the full report template
2. Research each dimension — Query all relevant ToolUniverse tools per dimension
3. Update report progressively — Write findings to the file after completing each dimension
4. Include citations — Every fact must reference the source tool that provided it

The 10 Research Dimensions

#	Dimension	Key Focus
1	Disease Identity & Classification	EFO, ICD-10, UMLS, SNOMED identifiers; synonyms; disease hierarchy
2	Clinical Presentation	HPO phenotypes; symptoms and signs; diagnostic criteria
3	Genetic & Molecular Basis	Associated genes; GWAS associations; ClinVar pathogenic variants
4	Treatment Landscape	Approved drugs; clinical trials; treatment guidelines
5	Biological Pathways & Mechanisms	Reactome pathways; PPI networks; tissue expression
6	Epidemiology & Risk Factors	Prevalence; risk factors; GWAS studies
7	Literature & Research Activity	Publication trends; key papers; research institutions
8	Similar Diseases & Comorbidities	Disease similarity scores; shared genetic basis
9	Cancer-Specific Information	CIViC variants; molecular profiles; targeted therapies (if applicable)
10	Drug Safety & Adverse Events	Drug warnings; trial adverse events; FAERS data

Example

User: "Research Parkinson's disease"

Agent actions (internal, not shown to user):
1. Create "parkinsons_disease_research_report.md" with template
2. Research DIM 1 → Update Identity section
3. Research DIM 2 → Update Clinical section
4. ... continue for all 10 dimensions
5. Present final report to user

Citation Requirements

Every piece of data in the report must include its source tool. The agent should use source columns in tables, [Source: tool_name] annotations in lists, and parenthetical (Source: tool_name, query: ...) references in prose. A complete tool usage log belongs in the References section at the end of the report.

Detailed References

For the full report template, complete tool listings per dimension, implementation examples, citation format guide, and quality checklist, see references/tool-reference.md.

Additional Resources

See TOOLS_REFERENCE.md for complete tool documentation. See EXAMPLES.md for sample reports.