DrugComb Query Skill

SkillDatabases & data

Query the DrugComb drug combination database for cancer cell-line synergy and sensitivity data. Use whenever the user asks about drug combinations, synergy scores (ZIP/Bliss/Loewe/HSA), combination sensitivity (CSS), or wants to look up how two drugs interact in a specific cancer cell line.

Instructions available. Your AI can read the instructions. Execution depends on the setup they require.

Account requirements not reviewed. Check the skill instructions before use; ahel provides instructions and does not run this skill.

Add ahel to your AI once: Claude, ChatGPT, Cursor, Claude Code or Codex. Then ask it to use this.

Then ask your AI: use the DrugComb Query Skill skill

What this skill tells your AI

The instructions your AI receives, as published by qsong-github/drugclaw in skills/drug_combination/drugcomb/SKILL.md and read by ahel’s review.

Search DrugComb summary records by any entity. Auto-detects type by pattern:

Input Pattern	Detected As	Match Logic
`5-FU` / `imatinib`	drug name	case-insensitive substring on `drug_row` OR `drug_col`
`A549` / `MCF-7`	cell line	case-insensitive substring on `cell_line_name`
`12345` (pure digits)	block_id	exact on `block_id`
`CID:2244`	PubChem CID	exact on `drug_row_cid` OR `drug_col_cid`

API

Function	Input	Returns
`load_drugcomb(path)`	CSV path	`list[dict]`
`columns(data)`	loaded data	column name list
`search(data, entity)`	single entity string	`list[dict]`
`search_batch(data, entities)`	list of entity strings	`dict[str, list[dict]]`
`summarize(hits, entity)`	hit list + label	compact LLM-readable text
`to_json(hits)`	hit list	`list[dict]`

Usage

See if __name__ == "__main__" block in example.py for runnable examples covering: drug name search, cell-line search, batch search, and JSON output.

Data

Source: DrugComb normalized full-package output
Key columns: drug_row, drug_col, cell_line_name, synergy_zip, synergy_bliss
Path: resources_metadata/drug_combination/DrugComb/drugcomb.csv

Citation

Zagidullin B, Aldahdooh J, Zheng S, et al. DrugComb: an integrative cancer drug combination data portal. Nucleic Acids Res. 2019;47(W1):W43–W51. doi:10.1093/nar/gkz337

Signals

GitHub stars: 116
Forks: 3
Last commit: Aug 2026

Advanced

Item type: skill
Key: drugcomb
Source: github.com/qsong-github/drugclaw

github.com/qsong-github/drugclaw