pipeline-analysis

Methodology inspired by publicly taught pipeline-valuation frameworks; all text is an original paraphrase.

Defaults

Parameter	Default Value	Rationale
asset_scope	all disclosed assets	Full-pipeline enumeration first
include_devices	true	Devices via PMA/De Novo share catalyst logic
valuation_frame	risk-adjusted	rNPV-style thinking, not raw NPV

Preflight

Run canonical pre-flight per contracts/preflight.md. Propagate X-Agentii-Trace per contracts/x-agentii-trace-header.md.

Triggers

• "Analyze [biotech ticker]'s pipeline."
• "What's in [ticker]'s clinical portfolio?"
• "Map [ticker]'s assets by phase and indication."
• "What are [ticker]'s next catalysts?"
• "How much runway does [ticker] have?"
• "Risk-adjusted view of [ticker]'s pipeline value."
• "Which of [ticker]'s programs matter most?"
• "Pipeline deep-dive for [ticker]."
• "What devices does [ticker] have in the works?"
• "Compare [ticker]'s pipeline to its peers."

Production Grounding

• Enumerate assets from get_company_drugs/get_company_devices (049 universes); supplement with filings (search_sec_filings, read_source_*) for trial phase/status.
• Phase-aware valuation: discovery/preclinical minimal; P1/P2 option-value; P3/registered majority of risk-adjusted value. Apply AdCom-style scrutiny axes when sizing pivotal-stage assets (per references/knowledge-frameworks.md).
• Cash runway (quarters) gates which catalysts the company can reach; funding risk is pipeline risk.

Data Source Priority

1. get_company_drugs / get_company_devices — asset inventory from the 049 universes.
2. search_sec_filings / read_source_* — phase, status, trial data, guidance.
3. search_xbrl_facts — cash/R&D spend for runway.
4. Knowledge layer: search_investment_strategies(sectors=med) + cases for playbook grounding.

Methodology

Retrieval Scope

unstructured_document_search

Retrieval Strategy

1. Pull asset inventory (get_company_drugs/get_company_devices).
2. Enrich per-asset phase/status/next-catalyst from filings.
3. Compute runway from balance-sheet facts.
4. Size each asset risk-adjusted; ground in strategies/cases.

Temporal Scope

See frontmatter temporal_scope block.

Tool Allowlist

See frontmatter allowed_tools.

Protocol

1. Asset enumeration
2. Phase/status enrichment
3. Runway assessment
4. Risk-adjusted synthesis

Modes

• Full pipeline (default): all assets with catalysts.
• Value-drivers: only the top risk-adjusted assets.
• Runway-focused: funding-requirement analysis.

Tool Fallbacks

Failure	Fallback
get_company_drugs empty	Reconstruct from filings keyword search; annotate coverage_gap
No cash data	Flag runway unavailable
Knowledge tools empty	Proceed with structured data only

Output File

{ticker}/{YYYY-MM-DD_HHMM}_pipeline-analysis_{affix}.md

Output Structure

1. Executive Summary — pipeline stance in 2-3 sentences
2. Asset Table — phase, indication, next catalyst, risk-adjusted sizing
3. Value Drivers — top assets with scrutiny-axes assessment
4. Runway & Funding — quarters of cash, funding needs
5. Historical Context — strategies/cases with /v/ citations
6. Coverage Gaps — degraded flags

Error Handling

Error	Fallback
Phase unknown	Mark "undisclosed"; do not guess
No catalysts found	Say so explicitly; note pipeline may be early-stage

Memory Load

See contracts/memory-load.md.

Snapshot

See contracts/snapshot-synthesis.md.

Final Summary (TUI)

Include ### Key Citations block with 0-10 clickable /v/ URLs.

References

• contracts/citation-and-memory.md
• contracts/output-frontmatter-schema.md
• contracts/memory-load.md
• contracts/snapshot-synthesis.md
• contracts/preflight.md
• references/knowledge-frameworks.md