SIDER - Side Effect Resource

Category: Drug-centric | Type: DB | Subcategory: Adverse Drug Reaction (ADR) Link: http://sideeffects.embl.de/ | Paper: https://doi.org/10.1093/nar/gkv1075

SIDER contains marketed medicines and their recorded adverse drug reactions, mined from public documents and package inserts.

Entity Type Auto-Detection

Input Pattern	Detected As	Example
CIDxxxxxxxxx	STITCH ID	CID100000085
Cxxxxxxx (8-char, digits after C)	UMLS CUI	C0011849
X##XX## (7-char ATC pattern)	ATC code	N05BA01
anything else	free text	aspirin, headache

Free text first attempts exact/substring match on drug names; if no drug is matched, it searches side-effect and indication names.

API

Function	Input	Returns
search(entity)	single entity string	dict with drug_name, stitch_ids, atc_codes, side_effects, indications, freq
search_batch(entities)	list of entity strings	dict[str, dict]
summarize(result)	one result dict	compact text string
to_json(result)	one result dict	same dict (pipeline passthrough)

Usage

from 14_SIDER import search, search_batch, summarize

# Single query — drug name
result = search("aspirin")
print(summarize(result))

# Single query — STITCH ID
result = search("CID100000085")
print(summarize(result))

# Single query — side-effect text
result = search("headache")
print(summarize(result))

# Batch query — mixed entity types
results = search_batch(["metformin", "ibuprofen", "C0011849"])
for entity, r in results.items():
    print(summarize(r))

Data Files

All pre-downloaded and extracted under: resources_metadata/adr/SIDER

File	Content
drug_names.tsv	STITCH flat ID → drug name
drug_atc.tsv	STITCH flat ID → ATC code
meddra_all_se.tsv	All side effects (STITCH, UMLS, MedDRA type, SE name)
meddra_all_indications.tsv	All indications (STITCH, UMLS, method, MedDRA name)
meddra_freq.tsv	Side effects with frequency info

The loader auto-detects .tsv / .tsv.gz variants. Results are capped at 50 records per category for readability.