TMB-MSI Calculator Skill
SkillDev toolsTumor mutation burden and microsatellite instability calculation skill for immunotherapy biomarkers
Instructions available. Your AI can read the instructions. Execution depends on the setup they require.
Account requirements not reviewed. Check the skill instructions before use; ahel provides instructions and does not run this skill.
Add ahel to your AI once: Claude, ChatGPT, Cursor, Claude Code or Codex. Then ask it to use this.
Then ask your AI: use the TMB-MSI Calculator Skill skill
What this skill tells your AI
The instructions your AI receives, as published by a5c-ai/babysitter in library/specializations/domains/science/bioinformatics/skills/tmb-msi-calculator/SKILL.md and read by ahel’s review.
Purpose
Calculate tumor mutation burden and microsatellite instability for immunotherapy biomarker assessment.
Capabilities
- TMB calculation from VCF
- MSI status determination
- Neoantigen prediction
- HLA typing integration
- Biomarker thresholds
- Clinical report generation
Usage Guidelines
- Calculate TMB with appropriate normalization
- Determine MSI status accurately
- Predict neoantigens for immunotherapy
- Apply clinical thresholds for reporting
- Generate actionable reports
- Document methodology and thresholds
Dependencies
- TMBcat
- MSIsensor2
- MANTIS
Process Integration
- Tumor Molecular Profiling (tumor-molecular-profiling)
Signals
- GitHub stars
- 2k
- Forks
- 112
- Last commit
- Sep 2026
Advanced
- Item type
- skill
- Key
tmb-msi-calculator- Source
- github.com/a5c-ai/babysitter