LTKB Query Skill

SkillDatabases & data

Query the DILIrank/FDA Liver Toxicity Knowledge Base (LTKB). Use whenever the user asks about drug-induced liver injury (DILI) risk, hepatotoxicity classification, or wants to look up any drug (by name, LTKB ID, or DILIst ID) in the DILIrank or DILIst datasets.

Instructions available. Your AI can read the instructions. Execution depends on the setup they require.

Account requirements not reviewed. Check the skill instructions before use; ahel provides instructions and does not run this skill.

Add ahel to your AI once: Claude, ChatGPT, Cursor, Claude Code or Codex. Then ask it to use this.

Then ask your AI: use the LTKB Query Skill skill

What this skill tells your AI

The instructions your AI receives, as published by qsong-github/drugclaw in skills/drug_toxicity/dilirank/SKILL.md and read by ahel’s review.

Search FDA LTKB records (DILIrank 2.0 + DILIst) by any entity. Auto-detects type by pattern:

Input Pattern	Detected As	Searched In
`LT00040`	LTKB ID	DILIrank only
`2` (digits)	DILIst ID	DILIst only
anything else	drug name	both datasets (substring)

Datasets

DILIrank 2.0 — 1,036 FDA-approved drugs ranked by DILI concern:

vDILI-Concern	Meaning
vMOST-DILI-concern	Strong evidence of causing DILI
vLess-DILI-concern	Some evidence of causing DILI
vNo-DILI-concern	No credible evidence
vAmbiguous-DILI-concern	Conflicting/insufficient evidence

Columns: LTKBID, CompoundName, SeverityClass, LabelSection, vDILI-Concern, Comment

DILIst — 1,279 drugs classified by DILI severity:

Classification	Meaning
1	DILI-positive
0	DILI-negative

Columns: DILIST_ID, CompoundName, DILIst Classification, Routs of Administration

API

Function	Input	Returns
`load_all(rank_path, list_path)`	Excel paths	`{"dilirank": [...], "dilist": [...]}`
`search(data, entity)`	data dict + entity string	`{"entity", "type", "dilirank": [], "dilist": []}`
`search_batch(data, entities)`	data dict + list of strings	`{entity: search_result}`
`summarize(result, entity)`	search result + label	compact text
`to_json(result)`	search result	JSON string

Usage

See if __name__ == "__main__" block in 48_LTKB.py for runnable examples covering: drug name, LTKB ID, DILIst ID, batch search, and JSON output.

Data

Source: FDA LTKB — https://www.fda.gov/science-research/bioinformatics-tools/liver-toxicity-knowledge-base-ltkb
Files: Drug Induced Liver Injury Rank (DILIrank 2.0) Dataset FDA.xlsx, DILIst Supplementary Table.xlsx
Path: DATA_DIR variable in 48_LTKB.py

Signals

GitHub stars: 116
Forks: 3
Last commit: Aug 2026

ahel review

K1binfo
installs-packages (in example.py)

Automated review, not a security audit. Ruleset v1+k2.

Advanced

Item type: skill
Key: x-48-ltkb
Source: github.com/qsong-github/drugclaw

github.com/qsong-github/drugclaw